Oral leiomyosarcoma in a dogOral leiomyosarcoma in a dog
- Other Titles
- Oral leiomyosarcoma in a dog
- Authors
- 김영주; 전예슬; 배현아; 신선우; 조아롬; 현재은; 황태성; 홍일화; 이희천; 정동인; 조규완; 유도현
- Issue Date
- 2021
- Publisher
- 충북대학교 동물의학연구소
- Keywords
- leiomyosarcoma; mouth neoplasms; immunohistochemistry; vimentin; desmin
- Citation
- Journal of Biomedical and Translational Research, v.22, no.4, pp.199 - 204
- Indexed
- KCI
OTHER
- Journal Title
- Journal of Biomedical and Translational Research
- Volume
- 22
- Number
- 4
- Start Page
- 199
- End Page
- 204
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/4780
- ISSN
- 2508-1357
- Abstract
- Leiomyosarcoma is malignant mesenchymal tumor of smooth muscle and commonly en-countered in the gastrointestinal tract of dogs. However, primary canine leiomyosarcoma in oral cavity is rare due to lack of smooth muscle in the oral tissue. A 13-year-old, neutered male Poodle presented a hard and immobile mass on the left maxilla. Imprinting cytology from the mass as well as fine-needle aspirated cytology from the left scapular lymph node revealed predominant spindle cells met malignancy criteria of the tumors, including coarse chromatin, high N/C ratio, nuclear molding, macro/multi-nucleoli with cigar-shaped nucleus.
Radiography of the skull showed lysis of the nasopalatine bone, and mineral radiopacity in the mass. Computed tomography showed soft tissue attenuating mass from the left incisor teeth to the left retrobulbar space with loss of nasopalatine bone and medial wall of orbit. The histopathological examination showed irregularly arranged malignant spindle-shaped cells with oval or elongated nuclei. The nucleolus is distinct and moderate cellular polymorphism is observed. Mitotic figures are occasionally observed. The tumor cells are positive to vimentin, desmin, α-smooth muscle actin when immunohistochemistry was performed, and in Mas-son’s trichrome stain, tumor cells are stained as red. Overall, histopathologic exam and im-munohistochemistry confirmed canine oral leiomyosarcoma. Because of the poor prognosis, the owner did not consent further treatment.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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