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Effects of Vitamin E on the immune system and tumor growth during radiotherapy

Authors
Gu, Yeun-HwaKang, Ki-MunYamashita, TakenoriSong, Jin Ho
Issue Date
Jan-2021
Publisher
Medknow Publications
Keywords
Immunity; lymphocytes; radiotherapy; tumor; Vitamin E
Citation
Journal of Cancer Research and Therapeutics, v.17, no.1, pp 211 - 217
Pages
7
Indexed
SCIE
SCOPUS
Journal Title
Journal of Cancer Research and Therapeutics
Volume
17
Number
1
Start Page
211
End Page
217
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/4330
DOI
10.4103/jcrt.JCRT_706_18
ISSN
0973-1482
1998-4138
Abstract
Purpose: The purpose of this study is to evaluate the effects of Vitamin E (VE) on the immune system and tumor growth during radiotherapy (RT) in mice model. Methods: C57BL/6NCrSlc mice were randomly distributed in four groups (control, VE alone, RT alone, and VE + RT). In the VE and VE + RT groups, VE was administered in the diet at 500 mg/kg. Radiation was delivered at 2 Gy in a single fraction on the whole body or at 6 Gy in three fractions locally in the RT and VE + RT groups. Changes in leukocytes and T lymphocytes were counted and compared between the four groups. To evaluate the effects on tumor growth, Ehrlich carcinoma cells were injected into the thighs of mice, and tumor volumes and growth inhibition rates were compared. Results: The number of leukocytes was increased in the VE group compared with that in the control group. The magnitude of leukocyte recovery after RT was also increased by VE. This change was affected largely by alterations in lymphocytes and monocytes rather than that in granulocytes. Both CD4+ and CD8+ T lymphocytes were positively affected by VE. The tumor growth was inhibited not only by RT but also by VE alone. If RT was delivered with VE, tumor growth was markedly inhibited. Conclusion: VE could increase the number of leukocytes, primarily lymphocytes, even after RT was delivered. VE also inhibited the tumor growth in addition to RT. Thus, VE may be a useful radioprotective supplement in radiotherapy without inducing tumor growth.
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의과대학 (의학과)
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