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Cited 9 time in webofscience Cited 11 time in scopus
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Aligned Nanofiber-Guided Bone Regeneration Barrier Incorporated with Equine Bone-Derived Hydroxyapatite for Alveolar Bone Regenerationopen access

Authors
Lim, Jae WoonJang, Kyoung JeSon, HyunmokPark, SangbaeKim, Jae EunKim, Hong BaeSeonwoo, HoonChoung, Yun HoonLee, Myung ChulChung, Jong Hoon
Issue Date
Jan-2021
Publisher
MDPI
Keywords
osteogenesis; equine bone; hydroxyapatite; nanofiber; regeneration barrier
Citation
POLYMERS, v.13, no.1
Indexed
SCIE
SCOPUS
Journal Title
POLYMERS
Volume
13
Number
1
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/4323
DOI
10.3390/polym13010060
Abstract
Post-surgery failure of dental implants due to alveolar bone loss is currently critical, disturbing the quality of life of senior dental patients. To overcome this problem, bioceramic or bone graft material is loaded into the defect. However, connective tissue invasion instead of osteogenic tissue limits bone tissue regeneration. The guided bone regeneration concept was adapted to solve this problem and still has room for improvements, such as biochemical similarity or oriented structure. In this article, an aligned electrospun-guided bone regeneration barrier with xenograft equine bone-derived nano hydroxyapatite (EBNH-RB) was fabricated by electrospinning EBNH/PCL solution on high-speed rotating drum collector and fiber characterization, viability and differentiation enhancing properties of mesenchymal dental pulp stem cell on the barrier was determined. EBNH-RB showed biochemical and structural similarity to natural bone tissue electron microscopy image analysis and x-ray diffractometer analysis, and had a significantly better effect in promoting osteogenesis based on the increased bioceramic content by promoting cell viability, calcium deposition and osteogenic marker expression, suggesting that they can be successfully applied to regenerate alveolar bone as a guided bone regeneration barrier.
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Jang, Kyung Je
농업생명과학대학 (생물산업기계공학과)
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