Detailed Information

Cited 14 time in webofscience Cited 16 time in scopus
Metadata Downloads

Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Deathopen access

Authors
Shin, Hyun JooJeong, Eun AeLee, Jong YoulAn, Hyeong SeokJang, Hye MinAhn, Yu JeongLee, JaewoongKim, Kyung EunRoh, Gu Seob
Issue Date
Jan-2021
Publisher
MDPI
Keywords
kainic acid; lipocalin-2; oxidative stress; neuroinflammation; hippocampus
Citation
ANTIOXIDANTS, v.10, no.1
Indexed
SCIE
SCOPUS
Journal Title
ANTIOXIDANTS
Volume
10
Number
1
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/4303
DOI
10.3390/antiox10010100
ISSN
2076-3921
Abstract
The hippocampal cell death that follows kainic acid (KA)-induced seizures is associated with blood-brain barrier (BBB) leakage and oxidative stress. Lipocalin-2 (LCN2) is an iron-trafficking protein which contributes to both oxidative stress and inflammation. However, LCN2 ' s role in KA-induced hippocampal cell death is not clear. Here, we examine the effect of blocking LCN2 genetically on neuroinflammation and oxidative stress in KA-induced neuronal death. LCN2 deficiency reduced neuronal cell death and BBB leakage in the KA-treated hippocampus. In addition to LCN2 upregulation in the KA-treated hippocampus, circulating LCN2 levels were significantly increased in KA-treated wild-type (WT) mice. In LCN2 knockout mice, we found that the expressions of neutrophil markers myeloperoxidase and neutrophil elastase were decreased compared to their expressions in WT mice following KA treatment. Furthermore, LCN2 deficiency also attenuated KA-induced iron overload and oxidative stress in the hippocampus. These findings indicate that LCN2 may play an important role in iron-related oxidative stress and neuroinflammation in KA-induced hippocampal cell death.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Roh, Gu Seob photo

Roh, Gu Seob
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE