Case Report: Long-Term Chemotherapy With Hydroxyurea and Prednisolone in a Cat With a Meningioma: Correlation of FDG Uptake and Tumor Grade Assessed by Histopathology and Expression of Ki-67 and p53open access
- Authors
- Yun, Taesik; Koo, Yoonhoi; Kim, Hakhyun; Lee, Wonguk; Kim, Soochong; Jung, Dong-In; Yang, Mhan-Pyo; Kang, Byeong-Teck
- Issue Date
- 26-Jan-2021
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- brain tumor; chemotherapy; feline; hydroxyurea; positron emission tomography
- Citation
- FRONTIERS IN VETERINARY SCIENCE, v.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN VETERINARY SCIENCE
- Volume
- 8
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/4215
- DOI
- 10.3389/fvets.2021.576839
- ISSN
- 2297-1769
- Abstract
- A 15.5-year-old, neutered, male, domestic shorthair cat was presented with neurologic dysfunctions. At presentation, an obtunded mental status and vestibular ataxia were identified. On neurologic examination, postural reactions were decreased-to-absent in all four limbs, and pupillary light reflexes showed bilaterally delayed results. Magnetic resonance imaging was performed, and a demarcated lesion was identified in the third ventricle. The cat was tentatively diagnosed with a brain tumor, which was suspected to be a meningioma. The cat was treated with hydroxyurea and prednisolone. Mental status was considered more alert, and ataxia improved following treatment. On the 106th day after the commencement of treatment, a F-18-fluorodeoxyglucose (FDG)-positron emission tomography (PET) scan was performed. On the PET images, a hypermetabolic region was found in the lesion. The average standardized uptake value of FDG was 2.47, and the tumor-to-normal-tissue ratio was 1.25. The cat died 408 days following the commencement of treatment, and a grade 1 meningioma was confirmed by postmortem histopathology. Immunohistochemistry for Ki-67 and p53 was performed. The labeling indices of Ki-67 and p53 were 2.56 and 0%, respectively. This case shows that chemotherapy with hydroxyurea and prednisolone may be considered in the treatment of feline meningiomas. Furthermore, this is the first case describing the application of FDG-PET to visualize a naturally occurring meningioma in a cat.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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