IgG4-related disease presenting as otogenic skull base osteomyelitisopen access
- Yim, Chae Dong; An, Hyo Jung; Ahn, Seong Ki; Hur, Dong Gu; Lee, Hyun-Jin
- Issue Date
- ELSEVIER SCI LTD
- IgG4-related disease; Skull base osteomyelitis
- AURIS NASUS LARYNX, v.48, no.1, pp.166 - 170
- Journal Title
- AURIS NASUS LARYNX
- Start Page
- End Page
- IgG4-related disease (IgG4-RD) is an emerging clinical disease entity characterized by tumefactive lesions at multiple sites with a dense lymphoplasmacytic infiltrate rich in IgG4+ plasma cells. Although almost any organ can be affected, IgG4-RD is most likely to involve the submandibular, lacrimal, or parotid glands in the head and neck region. However, skull base involvement presenting as otogenic skull base osteomyelitis (SBO) is rare. We encountered a 70-year-old male with IgG4-RD presenting primarily with severe otalgia and otorrhea. He had uncontrolled diabetes mellitus and showed clinical manifestations of otogenic SBO. Tissue immunostaining revealed typical features of increased IgG4-positive plasma cells, and hematological examination showed elevated serum IgG4 concentrations. Treatment with corticosteroids significantly improved wellbeing and partially resolved the lesion based on computed tomography (CT) scan. (c) 2020 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.
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- College of Medicine > Department of Medicine > Journal Articles
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