Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Dong-Ju | - |
dc.contributor.author | Kang, Ju-Bin | - |
dc.contributor.author | Shah, Fawad-Ali | - |
dc.contributor.author | Koh, Phil-Ok | - |
dc.date.accessioned | 2022-12-26T10:45:27Z | - |
dc.date.available | 2022-12-26T10:45:27Z | - |
dc.date.created | 2022-12-12 | - |
dc.date.issued | 2021-02-25 | - |
dc.identifier.issn | 1738-6055 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/4074 | - |
dc.description.abstract | Background Calcium is a critical factor involved in modulation of essential cellular functions. Parvalbumin is a calcium buffering protein that regulates intracellular calcium concentrations. It prevents rises in calcium concentrations and inhibits apoptotic processes during ischemic injury. Quercetin exerts potent antioxidant and anti-apoptotic effects during brain ischemia. We investigated whether quercetin can regulate parvalbumin expression in cerebral ischemia and glutamate toxicity-induced neuronal cell death. Adult male rats were treated with vehicle or quercetin (10 mg/kg) 30 min prior to middle cerebral artery occlusion (MCAO) and cerebral cortical tissues were collected 24 h after MCAO. We used various techniques including Western blot, reverse transcription-PCR, and immunohistochemical staining to elucidate the changes of parvalbumin expression. Results Quercetin ameliorated MCAO-induced neurological deficits and behavioral changes. Moreover, quercetin prevented MCAO-induced a decrease in parvalbumin expression. Conclusions These findings suggest that quercetin exerts a neuroprotective effect through regulation of parvalbumin expression. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.subject | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject | GENE-EXPRESSION ANALYSIS | - |
dc.subject | RAT-BRAIN | - |
dc.subject | CALCIUM | - |
dc.subject | ISCHEMIA | - |
dc.subject | INJURY | - |
dc.subject | CELLS | - |
dc.subject | CA2+ | - |
dc.subject | NEURONS | - |
dc.subject | STROKE | - |
dc.title | Quercetin attenuates the reduction of parvalbumin in middle cerebral artery occlusion animal model | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Koh, Phil-Ok | - |
dc.identifier.doi | 10.1186/s42826-021-00086-0 | - |
dc.identifier.wosid | 000704604400001 | - |
dc.identifier.bibliographicCitation | LABORATORY ANIMAL RESEARCH, v.37, no.1 | - |
dc.relation.isPartOf | LABORATORY ANIMAL RESEARCH | - |
dc.citation.title | LABORATORY ANIMAL RESEARCH | - |
dc.citation.volume | 37 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002700095 | - |
dc.description.journalClass | 2 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | GENE-EXPRESSION ANALYSIS | - |
dc.subject.keywordPlus | RAT-BRAIN | - |
dc.subject.keywordPlus | CALCIUM | - |
dc.subject.keywordPlus | ISCHEMIA | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | CA2+ | - |
dc.subject.keywordPlus | NEURONS | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordAuthor | Cerebral ischemia | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | Parvalbumin | - |
dc.subject.keywordAuthor | Quercetin | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.