Expression Patterns of ER alpha, ER beta, AR, SIRT1, SIRT2, and SIRT3 in Prostate Cancer Tissue and Normal Prostate Tissue
- Choi, Jae Hwi; Choi, See Min; Lee, Sin Woo; Jeh, Seong Uk; Hyun, Jae Seog; Lee, Min Ho; Lee, Chunwoo; Kam, Sung Chul; Kim, Dong Chul; Lee, Jong Sil; Hwa, Jeong Seok
- Issue Date
- INT INST ANTICANCER RESEARCH
- ? estrogen receptor; the androgen receptor; SIRT1; SIRT2; SIRT3
- ANTICANCER RESEARCH, v.41, no.3, pp.1377 - 1386
- Journal Title
- ANTICANCER RESEARCH
- Start Page
- End Page
- Background/Aim: The purpose of this study was to examine the expression of estrogen receptor ? (ER?) and ? (ER?), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa). Materials and Methods: From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa. Results: ER? and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development. Conclusion: AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.
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- College of Medicine > Department of Medicine > Journal Articles
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