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Cited 2 time in webofscience Cited 3 time in scopus
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Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy

Authors
Kim, Tae-WoonKo, Young JunYoun, Ki-HyokHwang, Boo-GeunBang, Hyun-SeokLee, Sam-Jun
Issue Date
Apr-2021
Publisher
KOREAN SOC EXERCISE REHABILITATION
Keywords
Maternal stress; Treadmill exercise; Spatial learning ability; Cell proliferation; Brain-derived neurotrophic factor; Apoptosis
Citation
JOURNAL OF EXERCISE REHABILITATION, v.17, no.2, pp.88 - 95
Indexed
SCOPUS
Journal Title
JOURNAL OF EXERCISE REHABILITATION
Volume
17
Number
2
Start Page
88
End Page
95
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3940
DOI
10.12965/jer.2142196.098
ISSN
2288-176X
Abstract
Prenatal stress causes learning deficits by inhibiting neurogenesis in the hippocampus. We studied the effects of maternal treadmill running or offspring treadmill running on the spatial learning ability of adolescent offspring rats or adult offspring rats born to maternal rats that received stress during pregnancy. For this study, spatial learning ability was measured by radial 8-arm maze task. Immunohistochemistry for 5-bromo-2 '-deoxyuridine and Western blot for brain-derived neurotrophic factor IBDNF), tyrosine kinase B (TrkB), Bcl-2-associated X protein IBax), and B-cell lymphoma 2 (Bcl-2) were also conducted. Stress was induced by exposing pregnant rats to hound in an enclosed room. Maternal treadmill running or treadmill running of offspring improved spatial learning ability of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring increased hippocampal cell proliferation of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring increased BDNF and TrkB expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring inhibited Bax expression and increased Bcl-2 expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Mother's exercise during pregnancy or child's exercise after childbirth can improve the spatial learning ability deteriorated due to stress during pregnancy.
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본부대학 (휴먼헬스케어학과)
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