Clinical characteristics and prognostic factors in hypertensive anterior uveitis diagnosed with polymerase chain reactionopen access
- Yoo, Woong-Sun; Kim, Gyu-Nam; Chung, Inyoung; Cho, Min-Chul; Han, Yong Seop; Kang, Sang Soo; Yun, Seung Pil; Seo, Seong-Wook; Kim, Seong-Jae
- Issue Date
- NATURE PORTFOLIO
- SCIENTIFIC REPORTS, v.11, no.1
- Journal Title
- SCIENTIFIC REPORTS
- Aim of the study is to report the clinical characteristics and prognostic factors in hypertensive anterior uveitis (AU) diagnosed with multiplex polymerase chain reaction (PCR). Eighty-eight eyes of 88 patients with hypertensive AU were enrolled from 2015 to 2019 in a tertiary center in South Korea. All patients underwent multiplex PCR that was performed using aqueous humor samples collected at first visit to detect the DNA of six herpesviruses. Twenty-eight (31.8%) eyes were PCR positive. Herpes simplex virus was found in 6 (6.8%) eyes, varicella-zoster virus in 7 (8.0%) eyes, cytomegalovirus in 14 (15.9%) eyes, and Epstein-Barr virus in 1 (1.1%) eye. On multivariate regression analysis, PCR positivity was significantly associated with coin-shaped keratic precipitates (odds ratio (OR)=6.01, P=0.044). Recurrence and final visual acuity were significantly associated with a presumed diagnosis of viral endotheliitis (OR=21.69, P=0.04 and OR=6.3, P=0.004, respectively). This study showed the importance of PCR positivity, suggesting that identification of the virus through active PCR testing could affect the course, treatment, and prognosis of hypertensive AU.
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- College of Medicine > Department of Medicine > Journal Articles
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