Increased Incidence and Associated Risk Factors of Aspergillosis in Patients with Bronchiectasisopen access
- Yang, Bumhee; Kim, Taehee; Ryu, Jiin; Park, Hye Yun; Bin Hwangbo; Kong, Sun-Young; Kwon, Yong-Soo; Lee, Seung Jun; Ra, Seung Won; Oh, Yeon-Mok; Sohn, Jang Won; Choe, Kang Hyeon; Choi, Hayoung; Lee, Hyun
- Issue Date
- aspergillosis; bronchiectasis; epidemiology; risk factors
- JOURNAL OF PERSONALIZED MEDICINE, v.11, no.5
- Journal Title
- JOURNAL OF PERSONALIZED MEDICINE
- There are insufficient data regarding the relationship between non-cystic fibrosis bronchiectasis and incident aspergillosis. We performed a population-based, matched cohort study using data from the Korean National Health Insurance database between 2003 and 2013. The incidence of aspergillosis was 50/100,000 person-years in the bronchiectasis cohort and 11/100,000 person-years in the matched cohort (subdistribution hazard ratio, 4.53; 95% confidence interval (CI), 3.25-6.32). Among the bronchiectasis cohort, chronic obstructive pulmonary disease (adjusted HR, 1.95; 95% CI, 1.07-3.57), previous pulmonary tuberculosis (adjusted HR, 3.67; 95% CI, 2.03-6.64), and non-tuberculous mycobacterial pulmonary disease (adjusted HR, 11.25; 95% CI, 1.49-85.18) increased the risk of incident aspergillosis. The incidence of aspergillosis in patients with bronchiectasis was approximately 4.5-fold that in those without bronchiectasis. Comorbid pulmonary diseases-chronic obstructive pulmonary disease, previous pulmonary tuberculosis, and non-tuberculous mycobacterial pulmonary disease-significantly increased the risk of aspergillosis in patients with bronchiectasis. Our study indicates that close monitoring is warranted for aspergillosis in patients with bronchiectasis.
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- College of Medicine > Department of Medicine > Journal Articles
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