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Cited 3 time in webofscience Cited 4 time in scopus
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PD-1 Expression and its Correlation With Prognosis in Clear Cell Renal Cell Carcinomaopen access

Authors
Kim, Min HyeKo, Gyung HyukLee, Jeong HeeLee, Jong SilKim, Dong ChulYang, Jung WookAn, Hyo JungNa, Ji MinSong, Dae Hyun
Issue Date
May-2021
Publisher
INT INST ANTICANCER RESEARCH
Keywords
Clear cell renal cell carcinoma; PD-1; survival analysis; prognosis; immunohistochemistry
Citation
IN VIVO, v.35, no.3, pp.1549 - 1553
Indexed
SCIE
SCOPUS
Journal Title
IN VIVO
Volume
35
Number
3
Start Page
1549
End Page
1553
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3745
DOI
10.21873/invivo.12409
ISSN
0258-851X
Abstract
Background/Aim: Programmed death ligand-1 (PD-L1) and programmed death protein 1 (PD-1) expression levels in many tumors and their correlation with prognosis have been actively studied. However, studies on PD-1 expression and its prognostic value in clear cell renal cell carcinoma (ccRCC) are limited and controversial. In this study, we describe the expression of PD-1 and its prognostic significance and association with clinical features in patients with ccRCC. Materials and Methods: We obtained clinicopathological data from 166 patients with ccRCC who were treated at Gyeongsang National University Hospital, Jinju, Korea between January 2000 and December 2009. Tissue microarray blocks were made using representative paraffin blocks of ccRCC specimens. Two pathologists analyzed PD-L1 and PD-1 expression in both tumor and inflammatory cells. Results: PD-1 expression in tumor infiltrating inflammatory cells was significantly correlated with unfavorable disease-free survival (DFS) (p<0.001) and disease-specific survival (DSS) (p=0.002) in the univariate analysis. A statistically significant correlation between PD 1 expression and unfavorable DFS (p=0.025) was observed in the multivariate analysis. Conclusion: PD-1 expression in tumor-infiltrating inflammatory cells serves as an independent prognostic factor for unfavorable DSS in patients with ccRCC.
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