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Cited 7 time in webofscience Cited 8 time in scopus
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Acutely increased beta-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress responseopen access

Authors
Son, HyeonwiBaek, Ji HyeongKang, Jae SoonJung, SoonwoongChung, Hye JinKim, Hyun Joon
Issue Date
21-May-2021
Publisher
Academic Press
Keywords
Ketone body; beta-Hydroxybutyrate; Acute stress; Stress response; Prefrontal cortex
Citation
Biochemical and Biophysical Research Communications, v.554, pp 19 - 24
Pages
6
Indexed
SCIE
SCOPUS
Journal Title
Biochemical and Biophysical Research Communications
Volume
554
Start Page
19
End Page
24
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/3699
DOI
10.1016/j.bbrc.2021.03.062
ISSN
0006-291X
1090-2104
Abstract
Ketone bodies can be increased in the blood under certain physiological conditions, but their role under such conditions remains to be clarified. In the present study, we found the increment and usage of beta-hydroxybutyrate (BHB) in the prefrontal cortex (PFC) during acute stress. BHB levels increased in the blood and PFC after 30-min acute immobilization stress, and BHB dehydrogenase 1 increased in the PFC simultaneously, but not in the hippocampus. Moreover, increased levels of acetyl-CoA, pyruvate carboxylase, and glutamate dehydrogenase 1 were found in the PFC, implicating the metabolism of increased BHB in the brain. Thus, we checked the levels of glutamate, glutamine, and GABA and found increased levels of glutamate and glutamine in the stressed group compared with that in the control group in the PFC. Exogenous administration of BHB enhanced struggling behaviors under stressful conditions. Our results suggest that the metabolism of BHB from peripheral blood in the PFC may contribute to acute stress responses to escape stressful conditions. (C) 2021 The Authors. Published by Elsevier Inc.
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