Microvasculature and Nerve Fiber Layer-Ganglion Cell Inner Plexiform Layer Thickness in Type 2 Diabetesopen access
- Seo, Jin-Seok; Cho, Yong-Wun; Seo, Seong-Wook; Kim, Seong-Jae; Chung, In Young; Yoo, Woong-Sun
- Issue Date
- KOREAN OPHTHALMOLOGICAL SOC
- Diabetic retinopathy; Neurodegeneration; Optical coherence tomography; Optical coherence tomographic angiography
- JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY, v.62, no.6, pp.769 - 776
- Journal Title
- JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY
- Start Page
- End Page
- Purpose: To investigate thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and vessel density of the superficial and deep retinal vessels and choriocapillaris using swept source optical coherence tomography (SS-OCT) and angiography (OCTA) in type 2 diabetic patients without diabetic retinopathy (DR). Methods: Sixty-four eyes of type 2 diabetic patients without DR were included. A control group of 54 eyes without diabetes was also recruited. All patients underwent multimodal imaging evaluation using SS-OCT and OCTA. Results: Vessel density of the superficial and deep retinal vessels was not different between the study and control groups. A significant decrease in NFL-GCIPL complex thickness was observed in the study group compared to the control group. NFL-GCIPL thickness of the macula decreased with increased duration of diabetes. Conclusions: These results suggest that neurodegeneration might be an early change in the development of DR.
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- College of Medicine > Department of Medicine > Journal Articles
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