Cadmium, an Environmental Contaminant, Exacerbates Alzheimer's Pathology in the Aged Mice's Brainopen access
- Authors
- Ali, Tahir; Khan, Amjad; Alam, Sayed Ibrar; Ahmad, Sareer; Ikram, Muhammad; Park, Jun Sung; Lee, Hyeon Jin; Kim, Myeong Ok
- Issue Date
- 24-Jun-2021
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- Cadmium; reactive oxygen species; antioxidant genes Nrf-2; HO-1; Alzheimer' s disease; neurodegeneration
- Citation
- FRONTIERS IN AGING NEUROSCIENCE, v.13
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN AGING NEUROSCIENCE
- Volume
- 13
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3580
- DOI
- 10.3389/fnagi.2021.650930
- ISSN
- 1663-4365
- Abstract
- Cadmium (Cd) is an environmental contaminant, which is a potential risk factor in the progression of aging-associated neurodegenerative diseases. Herein, we have assessed the effects of chronic administration of Cd on cellular oxidative stress and its associated Alzheimer's disease (AD) pathologies in animal models. Two groups of mice were used, one group administered with saline and the other with Cd (1 mg/kg/day; intraperitoneally) for 3 months. After behavioral studies, molecular/biochemical (Immunoblotting, ELISAs, ROS, LPO, and GSH assays) and morphological analyses were performed. We observed an exacerbation of memory and synaptic deficits in chronic Cd-injected mice. Subacute and chronic Cd escalated reactive oxygen species (ROS), suppressed the master antioxidant enzymes, e.g., nuclear factor-erythroid 2-related factor 2 and heme oxygenase-1, and evoked the stress kinase phospho-c-Jun N-terminal kinase 1 signaling pathways, which may escalate AD pathologies possibly associated with amyloidogenic processes. These findings suggest the regulation of oxidative stress/ROS and its associated amyloid beta pathologies for targeting the Cd-exacerbated AD pathogenesis. In addition, these preclinical animal studies represent a paradigm for epidemiological studies of the human population exposed to chronic and subacute administration of Cd, suggesting avoiding environmental contaminants.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.