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Cited 2 time in webofscience Cited 3 time in scopus
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Impact of acute kidney injury on mortality in patients with acute variceal bleedingopen access

Authors
Kim, Jae HeonIm, Chang BinLee, Sang SooJeon, HankyuChoi, Jung WooKim, Hee JinCha, Ra RiCho, Hyun ChinLee, Jae MinHa, Chang YoonKim, Hyun JinKim, Tae HyoJung, Woon TaeLee, Ok-Jae
Issue Date
13-Jul-2021
Publisher
BMC
Keywords
Acute kidney injury; Liver cirrhosis; Acute variceal bleeding; Mortality; International Club of Ascites criteria
Citation
BMC GASTROENTEROLOGY, v.21, no.1
Indexed
SCIE
SCOPUS
Journal Title
BMC GASTROENTEROLOGY
Volume
21
Number
1
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3488
DOI
10.1186/s12876-021-01862-x
ISSN
1471-230X
Abstract
Background The effect of acute kidney injury (AKI) on patients with acute variceal bleeding (AVB) using the recently proposed International Club of Ascites (ICA) criteria is unclear. This study aimed to evaluate the incidence of AKI using the ICA criteria and factors associated with the outcomes in cirrhotic patients with AVB. Methods This retrospective cohort study included data of cirrhotic patients with AVB from two centers in Korea. The association of the ICA criteria for AKI with 6-week mortality was analyzed through univariate and multivariate analyses using the Cox proportional hazard model. Results In total, there were 546 episodes of AVB in 390 patients, of which 425 and 121 episodes were due to esophageal and gastric variceal bleeding, respectively. Moreover, 153 patients fulfilled the ICA criteria for AKI, and 64, 30, 39, and 20 patients were diagnosed with stages 1a, 1b, 2, and 3, respectively. Conversely, 97 patients developed AKI within 42 days as per the conventional criteria. The 6-week mortality rate was significantly higher in patients with ICA-AKI than in patients without ICA-AKI; the occurrence of ICA-AKI was an independent factor for predicting the 6-week mortality. Conclusion The ICA criteria could help diagnose renal dysfunction earlier, and presence of AKI is a predictor of mortality in patients with cirrhosis and AVB.
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