Detailed Information

Cited 10 time in webofscience Cited 11 time in scopus
Metadata Downloads

Molecular surveillance of malaria in the Central Highlands, Vietnam

Authors
Vo, Tuan CuongLe, Huong GiangKang, Jung-MiNaw, HaungFan, Chia-KwungTrinh, Nguyen Thi MinhQuang, Huynh HongNa, Byoung-Kuk
Issue Date
Aug-2021
Publisher
ELSEVIER IRELAND LTD
Keywords
Malaria; Plasmodium falciparum; Plasmodium vivax; Genetic diversity; Vietnam
Citation
PARASITOLOGY INTERNATIONAL, v.83
Indexed
SCIE
SCOPUS
Journal Title
PARASITOLOGY INTERNATIONAL
Volume
83
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/3402
DOI
10.1016/j.parint.2021.102374
ISSN
1383-5769
1873-0329
Abstract
Vietnam achieved outstanding success against malaria in the last few decades. The mortality and morbidity of malaria in Vietnam have decreased remarkably in recent years, but malaria is still a major public health concern in the country, particularly in the Central Highlands region. In this study, molecular analyses of malaria parasites in the Central Highlands were performed to understand the population structure and genetic diversity of the parasites circulating in the region. Plasmodium falciparum (68.7%) and P. vivax (27.4%) along with mixed infections with P. falciparum/P. vivax (3.9%) were detected in 230 blood samples from patients with malaria. Allele-specific nested-polymerase chain reaction (PCR) or PCR-restriction fragment length polymorphism (PCRRFLP) analyses of pfmsp-1, pfama-1, pvcsp, and pvmsp-1 revealed complex genetic makeup in P. falciparum and P. vivax populations of Vietnam. Substantial multiplicity of infection (MOI) was also identified, suggesting significant genetic diversity and polymorphism of P. falciparum and P. vivax populations in the Central Highlands of Vietnam. These results provide fundamental insight into the current patterns of dispersion and genetic nature of malaria parasites as well as for the development of malaria elimination strategies in the endemic region.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Na, Byoung Kuk photo

Na, Byoung Kuk
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE