Current Molecular Therapeutic Agents and Drug Candidates for Mycobacterium abscessusopen access
- Authors
- Quang, Nguyen Thanh; Jang, Jichan
- Issue Date
- 30-Aug-2021
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- Mycobacterium abscessus; anti-M; abscessus; antibiotics; drug resistance; drug discovery
- Citation
- FRONTIERS IN PHARMACOLOGY, v.12
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN PHARMACOLOGY
- Volume
- 12
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3361
- DOI
- 10.3389/fphar.2021.724725
- ISSN
- 1663-9812
- Abstract
- Mycobacterium abscessus has been recognised as a dreadful respiratory pathogen among the non-tuberculous mycobacteria (NTM) because of misdiagnosis, prolonged therapy with poor treatment outcomes and a high cost. This pathogen also shows extremely high antimicrobial resistance against current antibiotics, including the anti-tuberculosis agents. Therefore, current chemotherapies require a long curative period and the clinical outcomes are not satisfactory. Thus, there is an urgent need for discovering and developing novel, more effective anti-M. abscessus drugs. In this review, we sum the effectiveness of the current anti-M. abscessus drugs and drug candidates. Furthermore, we describe the shortcomings and difficulties associated with M. abscessus drug discovery and development.
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