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Cited 13 time in webofscience Cited 13 time in scopus
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Current Molecular Therapeutic Agents and Drug Candidates for Mycobacterium abscessusopen access

Authors
Quang, Nguyen ThanhJang, Jichan
Issue Date
30-Aug-2021
Publisher
FRONTIERS MEDIA SA
Keywords
Mycobacterium abscessus; anti-M; abscessus; antibiotics; drug resistance; drug discovery
Citation
FRONTIERS IN PHARMACOLOGY, v.12
Indexed
SCIE
SCOPUS
Journal Title
FRONTIERS IN PHARMACOLOGY
Volume
12
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/3361
DOI
10.3389/fphar.2021.724725
ISSN
1663-9812
Abstract
Mycobacterium abscessus has been recognised as a dreadful respiratory pathogen among the non-tuberculous mycobacteria (NTM) because of misdiagnosis, prolonged therapy with poor treatment outcomes and a high cost. This pathogen also shows extremely high antimicrobial resistance against current antibiotics, including the anti-tuberculosis agents. Therefore, current chemotherapies require a long curative period and the clinical outcomes are not satisfactory. Thus, there is an urgent need for discovering and developing novel, more effective anti-M. abscessus drugs. In this review, we sum the effectiveness of the current anti-M. abscessus drugs and drug candidates. Furthermore, we describe the shortcomings and difficulties associated with M. abscessus drug discovery and development.
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자연과학대학 (생명과학부)
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