Expression of Chicken NK-Lysin and Its Role in Chicken Coccidiosis Induced by Eimeria necatrixopen access
- Kim, Woo Hyun; Min, Wongi; Park, Kwang Il; Lillehoj, Hyun S.; Fernandez-Colorado, Cherry P.; Flores, Rochelle A.; Cammayo, Paula Leona T.; Binh Thanh Nguyen
- Issue Date
- KOREAN SOC PARASITOLOGY, SEOUL NATL UNIV COLL MEDI
- Eimeria necatrix; chicken; NK-lysin; antimicrobial peptide; coccidiosis
- KOREAN JOURNAL OF PARASITOLOGY, v.59, no.5, pp.439 - 445
- Journal Title
- KOREAN JOURNAL OF PARASITOLOGY
- Start Page
- End Page
- Coccidiosis in chickens is an intestinal parasitic disease caused by protozoan parasites named Eimeria spp. In some Eimeria infections, intestinal lymphocytes are known to highly express chicken NK-lysin (cNK-lysin), an antimicrobial peptide with anticoccidial activity. Therefore, this study aims to investigate the expression of cNK-lysin in E. necatrix-infected chickens and its role in E. necatrix infection. The expression of cNK-lysin transcript was significantly increased in E. necatrix sporozoites-treated lymphocytes. In E. necatrix infection, cNK-lysin transcript was induced in intestinal lymphocytes but not in the spleen. The recombinant cNK-lysin exhibited anticoccidial activity against E. necatrix sporozoites as well as immunomodulatory activity on macrophages by inducing proinflammatory cytokines. These results indicated that E. necatrix infection induces high local expression of cNK-lysin and the secreted cNK-lysin helps protect coccidiosis.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 수의과대학 > Department of Veterinary Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.