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Tandem Synthesis of Tetrasubstituted NH Pyrroles from Simple Nitriles
- Authors
- Kim, Hyeongsu; Xuan, Zi; Kim, Ju Hyun
- Issue Date
- 2-Nov-2021
- Publisher
- WILEY-V C H VERLAG GMBH
- Keywords
- tetrasubstituted pyrroles; nitriles; Blaise reaction; oxidative dimerization; tandem reaction
- Citation
- CHEMISTRY-AN ASIAN JOURNAL, v.16, no.21, pp.3336 - 3340
- Indexed
- SCIE
SCOPUS
- Journal Title
- CHEMISTRY-AN ASIAN JOURNAL
- Volume
- 16
- Number
- 21
- Start Page
- 3336
- End Page
- 3340
- ISSN
- 1861-4728
- Abstract
- An efficient tandem route to obtain tetrasubstituted NH pyrroles in a one-pot manner has been developed, staring from simple nitriles, ethyl bromoacetates, and zinc. This reaction involves oxidative dimerization of the zinc bromide complex of beta-enaminoesters using cerium ammonium nitrate (CAN) as an oxidant, affording 2,3,4,5-tetrasubstituted pyrroles in yields up to 91%.
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