Antifatigue and Anti-Inflammatory Effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge Complex Extracts in Physically Fatigued Mice
- Authors
- Huang, Wen Yan; Pan, Jeong Hoon; Jeong, Inhye; Oh, Seong Ju; Hyun, Yong Geon; Kim, Moon Seong; Han, Bok Kyung; Hong, Jiyoun; Koo, Yong Tae; Lee, Ki Won; Jin, Bora; Noh, Dongjin; Kim, Sangho; Kim, Jae Kyeom; Shin, Eui-Cheol; Kim, Young Jun
- Issue Date
- Dec-2022
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- Angelica gigas Nakai; antifatigue; anti-inflammatory; Astragalus membranaceus; Bunge; Cervus elaphus L
- Citation
- JOURNAL OF MEDICINAL FOOD, v.25, no.12, pp 1126 - 1132
- Pages
- 7
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 25
- Number
- 12
- Start Page
- 1126
- End Page
- 1132
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/30055
- DOI
- 10.1089/jmf.2022.K.0103
- ISSN
- 1096-620X
1557-7600
- Abstract
- Fatigue is a common complaint among people under stress, causing an array of negative effects on physical function. In this study, we investigated the antifatigue and anti-inflammatory effects of Cervus elaphus L., Angelica gigas Nakai, and Astragalus membranaceus Bunge complex extracts (CAA) using a treadmill stress test in animal models. The mice were administered various doses of CAA (50-200 mg/kg bw per day) once daily for 21 days. After exhaustive treadmill exercise, the running time of CAA-treated mice increased 1.5 times; fatigue-related biochemical parameters, including lactate dehydrogenase (similar to 30%), creatine kinase (similar to 20%), and proinflammatory cytokines interleukin (IL)-1 beta (similar to 10%), and IL-6 (similar to 10%) in the serum and muscle tissue were downregulated compared with those in exercised control mice. This study provides strong evidence for the prevention of CAA-induced inflammatory incidences mediated by the blockade of nuclear factor-kappa B activation. Collectively, our results indicate that CAA can alleviate symptoms of fatigue in mice as an effective anti-inflammatory agent.
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