Bioactive Porous Particles as Biological and Physical Stimuli for Bone Regeneration
- Authors
- Kim, Min Ji; Park, Jin-Ho; Lee, Jae-Hoon; Kim, Hyeonjo; Choi, Hyeon-Jong; Lee, Hee-Chun; Lee, Jin Ho; Byun, June-Ho; Oh, Se Heang
- Issue Date
- Dec-2022
- Publisher
- AMER CHEMICAL SOC
- Keywords
- growth factor; delivery system; physical stimulation; bone regeneration; leaf-stacked structure
- Citation
- ACS BIOMATERIALS SCIENCE & ENGINEERING, v.8, no.12, pp 5233 - 5244
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS BIOMATERIALS SCIENCE & ENGINEERING
- Volume
- 8
- Number
- 12
- Start Page
- 5233
- End Page
- 5244
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/29986
- DOI
- 10.1021/acsbiomaterials.2c00664
- ISSN
- 2373-9878
- Abstract
- Even though bony defects can be recovered to their original condition with full functionality, critical-sized bone injuries continue to be a challenge in clinical fields due to deficiencies in the scaffolding matrix and growth factors at the injury region. In this study, we prepared bone morphogenetic protein-2 (BMP-2)-loaded porous particles as a bioactive bone graft for accelerated bone regeneration. The porous particles with unique leaf-stacked morphology (LSS particles) were fabricated by a simple cooling procedure of hot polycaprolactone (PCL) solution. The unique leaf-stacked structure in the LSS particles provided a large surface area and complex release path for the sufficient immobilization of BMP-2 and sustained release of BMP-2 for 26 days. The LSS was also recognized as a topographical cue for cell adhesion and differentiation. In in vitro cell culture and in vivo animal study using a canine mandible defect model, BMP-2-immobilized LSS particles provided a favorable environment for osteogenic differentiation of stem cells and bone regeneration. In vitro study suggests a dual stimulus of bone mineral-like (leaf-stacked) structure (a physical cue) and continuously supplied BMP-2 (a biological cue) to be the cause of this improved healing outcome. Thus, LSS particles containing BMP-2 can be a promising bioactive grafting material for effective new bone formation.
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Collections - College of Medicine > Department of Medicine > Journal Articles
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