Detailed Information

Cited 0 time in webofscience Cited 2 time in scopus
Metadata Downloads

Enzymatic transformation products of phloretin as potent antiadipogenic compounds

Authors
Jeong, Gyeong HanCho, Jae-HyeonPark, Eui KyunKim, Tae Hoon
Issue Date
Dec-2021
Publisher
OXFORD UNIV PRESS
Keywords
polyphenol oxidase; phloretin oxidation; biotransformation; pancreatic lipase; adipocyte differentiation
Citation
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.85, no.12, pp.2352 - 2359
Indexed
SCIE
SCOPUS
Journal Title
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume
85
Number
12
Start Page
2352
End Page
2359
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/2964
DOI
10.1093/bbb/zbab168
ISSN
0916-8451
Abstract
Enzymatic structure modification of the representative chalcone phloretin (1) with polyphenol oxidase from Agaricus bisporus origin produced 2 new biphenyl-type phloreoxin (2) and phloreoxinone (3), and a previously undescribed (2R)-5,7,3',5'-tetrahydroxyflavanone (4). The structure of these new oxidized products 2-4 elucidated by interpreting the spectroscopic data (NMR and FABMS) containing the absolute stereochemistry is established by the analysis of the circular dichroism spectrum. Compared to the original phloretin, the new products (2) and (3) showed highly improved antiadipogenic potencies both toward pancreatic lipase and accumulation of 3T3-L1 cells. Also, phloreoxin (2) effectively inhibited the expression of C/EBP beta, PPAR gamma, and aP2 at the mRNA level in the 3T3 adipocytes. Thus, phloreoxin (2), containing a biphenyl moiety catalyzed by A. bisporus polyphenol oxidase, have the potential to influence the antiadipogenic capacity. [GRAPHICS] Enzymatic oxidation products 2 and 3 of phloretin as potent antiadipogenic effects.
Files in This Item
There are no files associated with this item.
Appears in
Collections
수의과대학 > Department of Veterinary Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Cho, Jae Hyeon photo

Cho, Jae Hyeon
수의과대학 (수의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE