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Cited 1 time in webofscience Cited 4 time in scopus
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Combined Water Extracts from Oxidation-Treated Leaves and Branches of Hovenia dulcis Has Anti-Hangover and Liver Protective Effects in Binge Alcohol Intake of Male Miceopen access

Authors
Je, JihyunSong, MiyoungBaek, Ji HyeongKang, Jae SoonChung, Hye JinLee, KwonsuPark, Sang WonKim, Hyun Joon
Issue Date
Dec-2021
Publisher
MDPI
Keywords
alcohol-induced liver injury; flavonoid catechin; anti-hangover; oxidative; nitrosative; Hovenia dulcis
Citation
NUTRIENTS, v.13, no.12
Indexed
SCIE
SCOPUS
Journal Title
NUTRIENTS
Volume
13
Number
12
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/2916
DOI
10.3390/nu13124404
ISSN
2072-6643
Abstract
Hovenia dulcis, known as the oriental raisin tree, is used for food supplements and traditional medicine for the liver after alcohol-related symptoms. However, little information exists about the use of its leaves and branches. In this study, we established a method to use the leaves and branches to develop anti-hangover treatment and elucidated the underlying mechanisms. Oxidation-treated leaves (OL) exhibited high antioxidant content comparable to that of the peduncles and showed an anti-hangover effect in male mice. The branch extract (BE) was enriched in the flavonoid catechin, approximately five times more than OL extract. The mixture of OL and BE (OLB) was formulated in a 2:1 ratio with frozen-dried extract weight and was tested for anti-hangover effects and protective properties against binge alcohol-induced liver injury. OLB showed better anti-hangover effect than OL. In addition to this anti-hangover effect, OLB protected the liver from oxidative/nitrosative damage induced by binge alcohol intake.
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