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Effects of 7-hydroxy-3-methoxycadalene on cell cycle, apoptosis and protein translation in A549 lung cancer cells
- Authors
- Jin, Hua; Kim, Hyun-Woo; Xu, Cheng-Xiong; Kwon, Jung-Taek; Hwang, Soon-Kyung; Lee, Eun-Sun; Chang, Seung-Hee; Park, Sung-Jin; Noh, Mi-Suk; Woo, Min-Ah; Yu, Kyeong-Nam; Lee, Hu-Jang; Choi, Joon-Weon; Choi, Don-Ha; Cho, Myung-Haing
- Issue Date
- 2007
- Publisher
- WILEY
- Keywords
- cadalene; lung cancer; apoptosis; cell cycle; protein translation
- Citation
- BIOFACTORS, v.29, no.2-3, pp 67 - 75
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOFACTORS
- Volume
- 29
- Number
- 2-3
- Start Page
- 67
- End Page
- 75
- ISSN
- 0951-6433
1872-8081
- Abstract
- Previously we reported that cadalene extracted from Zelkova serrata inhibited lung tumorigenesis in mice. However, the precise mechanism has not yet investigated. Here, we examined the effects of cadalene on signal pathways important for apoptosis, cell cycle. and protein translation in lung cancer cells. Our results showed that cadalene suppressed the expression of Akt and its phosphor-forms through controlling PI3K and PTEN. Cadalene also induced apoptosis through facilitating proapoptotic protein expression. In addition, cadalene caused cell cycle arrest and decreased mTOR-mediated protein translation. Taken together, cadalene may be developed as a lung cancer therapeutic agent in the future.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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