Transition Metal-Free, Methoxide-Catalyzed Synthesis of Pyridoindolones
- Authors
- Park, Sun-a; Park, Jong-Un; Kim, Ye Lim; Kim, Ju Hyun
- Issue Date
- 3-Dec-2021
- Publisher
- American Chemical Society
- Citation
- The Journal of Organic Chemistry, v.86, no.23, pp 17050 - 17062
- Pages
- 13
- Indexed
- SCIE
SCOPUS
- Journal Title
- The Journal of Organic Chemistry
- Volume
- 86
- Number
- 23
- Start Page
- 17050
- End Page
- 17062
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/2869
- DOI
- 10.1021/acs.joc.1c02176
- ISSN
- 0022-3263
1520-6904
- Abstract
- A simple transition metal-free strategy for the synthesis of pyrido[1,2-a]indolone derivatives has been devised through sodium methoxide-catalyzed intramolecular cyclization of 2-alkenylated N-pyrimidyl indoles. The reactions involved a Smiles rearrangement/cyclization cascade, which resulted in a new series of N-fused indoles, potentially applicable skeletons in medicinal chemistry. This reaction presents simple eco-friendly reaction conditions, a high atom- and cost-economy, a short reaction time, and a broad range of substrate scope with high reaction efficiency.
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