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Cited 6 time in webofscience Cited 6 time in scopus
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Transition Metal-Free, Methoxide-Catalyzed Synthesis of Pyridoindolones

Authors
Park, Sun-aPark, Jong-UnKim, Ye LimKim, Ju Hyun
Issue Date
3-Dec-2021
Publisher
American Chemical Society
Citation
The Journal of Organic Chemistry, v.86, no.23, pp 17050 - 17062
Pages
13
Indexed
SCIE
SCOPUS
Journal Title
The Journal of Organic Chemistry
Volume
86
Number
23
Start Page
17050
End Page
17062
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/2869
DOI
10.1021/acs.joc.1c02176
ISSN
0022-3263
1520-6904
Abstract
A simple transition metal-free strategy for the synthesis of pyrido[1,2-a]indolone derivatives has been devised through sodium methoxide-catalyzed intramolecular cyclization of 2-alkenylated N-pyrimidyl indoles. The reactions involved a Smiles rearrangement/cyclization cascade, which resulted in a new series of N-fused indoles, potentially applicable skeletons in medicinal chemistry. This reaction presents simple eco-friendly reaction conditions, a high atom- and cost-economy, a short reaction time, and a broad range of substrate scope with high reaction efficiency.
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