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Protein kinase C delta regulates anti-apoptotic alpha B-crystallin in the retina of type 2 diabetes
- Authors
- Kim, Y. H.; Choi, M. Y.; Kim, Y. S.; Han, J. M.; Lee, J. H.; Park, C. H.; Kang, S. S.; Choi, W. S.; Cho, G. J.
- Issue Date
- Dec-2007
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- alpha BC phosphorylation; retinal apoptosis; PKC delta; rottlerin; type 2 diabetes
- Citation
- NEUROBIOLOGY OF DISEASE, v.28, no.3, pp 293 - 303
- Pages
- 11
- Indexed
- SCIE
SCOPUS
- Journal Title
- NEUROBIOLOGY OF DISEASE
- Volume
- 28
- Number
- 3
- Start Page
- 293
- End Page
- 303
- ISSN
- 0969-9961
1095-953X
- Abstract
- We investigated the relationship between phosphorylation of alphaB-crystallin (alpha BC) and retinal apoptosis in type 2 diabetes. The retinas of male Otsuka Long-Evans Tokushima fatty (OLETF) rats at 24 and 35 weeks were used as an animal model for type 2 diabetes and sex- and age-matched Long-Evans Tokushima Otsuka (LETO) rats were used as controls. In the retinas of 35-week OLETF rats, the interaction between alpha BC and protein kinase C delta (PKC delta) among the PKC isozymes, alpha BC phosphorylation at Ser45 (S45p-alpha BC), TUNEL-positive apoptotic ganglion cells, several apoptotic signs, and colocalization of S45p-alpha BC and TUNEL significantly increased as compared with other groups while the alpha BC-Bax interaction greatly decreased. These changes were abolished by rottlerin treatment, a highly specific PKC 6 inhibitor. These results suggest that PKC 6 is involved in regulation of anti-apoptotic function of alpha BC in the retina of type 2 diabetes. (C) 2007 Elsevier Inc. All rights reserved.
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