Serum microRNA-185 Levels and Myocardial Injury in Patients with Acute ST-segment Elevation Myocardial Infarctionopen access
- Park, Jeong Rang; Ahn, Jong Hwa; Jung, Myeong Hee; Kim, Jin Hyun; Kang, Min Gyu; Kim, Kye Hwan; Jang, Jeong Yoon; Park, Hyun Woong; Koh, Jin-Sin; Hwang, Seok-Jae; Park, Yongwhi; Jeong, Young-Hoon; Kwak, Choong Hwan; Hwang, Jin-Yong
- Issue Date
- JAPAN SOC INTERNAL MEDICINE
- human microRNA; miR-185; myocardial infarction
- INTERNAL MEDICINE, v.61, no.2, pp.151 - 158
- Journal Title
- INTERNAL MEDICINE
- Start Page
- End Page
- Objective Human microRNA-185 (miR-185) has been reported to act as a regulator of fibrosis and angiogenesis in cancer. however, miR-185 has not been investigated in patients with ST-segment elevation myocardial infarction (STEMI). We hypothesized that the changes in miR-185 levels in STEMI patients are related to the processes of myocardial healing and remodeling. Methods Between January 2011 and December 2013, 145 patients with STEMI (65.9 +/- 11.6 years old; 41 women) were enrolled. Initial and discharge serum samples collected from 20 patients with STEMI and mixed sera from 8 healthy controls were analyzed by a microarray. A quantitative reverse transcription polymerase chain reaction (RT-qPCR) analysis of miR-185 was performed in all 145 patients. The correlation between the miR-185 levels and the clinical, laboratory, angiographic, and echocardiographic parameters was analyzed. Results The microarray analysis revealed a biphasic pattern in miR-185 levels, with an initial decrease followed by an increase at discharge. The miR-185 levels at discharge were significantly correlated with the troponin-I, CK-MB, and area under the curve of CK-MB levels. There was a positive correlation between the transforming growth factor-beta and miR-185 levels at discharge (rho=0.242, p=0.026). A high wall motion score index and a low ejection fraction, as measured by echocardiography, and high B-type natriuretic peptide level at one month after STEMI were related to high miR-185 levels. Conclusion Our results showed that elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling.
- Files in This Item
- There are no files associated with this item.
- Appears in
- College of Medicine > Department of Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.