Detailed Information

Cited 3 time in webofscience Cited 3 time in scopus
Metadata Downloads

Serum microRNA-185 Levels and Myocardial Injury in Patients with Acute ST-segment Elevation Myocardial Infarctionopen access

Authors
Park, Jeong RangAhn, Jong HwaJung, Myeong HeeKim, Jin HyunKang, Min GyuKim, Kye HwanJang, Jeong YoonPark, Hyun WoongKoh, Jin-SinHwang, Seok-JaePark, YongwhiJeong, Young-HoonKwak, Choong HwanHwang, Jin-Yong
Issue Date
2022
Publisher
Japanese Society of Internal Medicine/Nihon Naika Gakkai
Keywords
human microRNA; miR-185; myocardial infarction
Citation
Internal Medicine, v.61, no.2, pp 151 - 158
Pages
8
Indexed
SCIE
SCOPUS
Journal Title
Internal Medicine
Volume
61
Number
2
Start Page
151
End Page
158
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/2800
DOI
10.2169/internalmedicine.7594-21
ISSN
0918-2918
1349-7235
Abstract
Objective Human microRNA-185 (miR-185) has been reported to act as a regulator of fibrosis and angiogenesis in cancer. however, miR-185 has not been investigated in patients with ST-segment elevation myocardial infarction (STEMI). We hypothesized that the changes in miR-185 levels in STEMI patients are related to the processes of myocardial healing and remodeling. Methods Between January 2011 and December 2013, 145 patients with STEMI (65.9 +/- 11.6 years old; 41 women) were enrolled. Initial and discharge serum samples collected from 20 patients with STEMI and mixed sera from 8 healthy controls were analyzed by a microarray. A quantitative reverse transcription polymerase chain reaction (RT-qPCR) analysis of miR-185 was performed in all 145 patients. The correlation between the miR-185 levels and the clinical, laboratory, angiographic, and echocardiographic parameters was analyzed. Results The microarray analysis revealed a biphasic pattern in miR-185 levels, with an initial decrease followed by an increase at discharge. The miR-185 levels at discharge were significantly correlated with the troponin-I, CK-MB, and area under the curve of CK-MB levels. There was a positive correlation between the transforming growth factor-beta and miR-185 levels at discharge (rho=0.242, p=0.026). A high wall motion score index and a low ejection fraction, as measured by echocardiography, and high B-type natriuretic peptide level at one month after STEMI were related to high miR-185 levels. Conclusion Our results showed that elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Jang, Jeong Yoon  photo

Jang, Jeong Yoon 
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE