Minimizing a QTL region for intramuscular fat content by characterizing the porcine Phosphodiesterase 4B (PDE4B) geneopen access
- Authors
- Kim, Jae-Hwan; Ovilo, Cristina; Park, Eung-Woo; Fernandez, Almudena; Lee, Jun-Heon; Jeon, Jin-Tae; Lee, Jung-Gyu
- Issue Date
- 30-Jun-2008
- Publisher
- KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
- Keywords
- intramuscular fat; PDE4B; positional candidate; quantitative trait loci
- Citation
- BMB REPORTS, v.41, no.6, pp.466 - 471
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- BMB REPORTS
- Volume
- 41
- Number
- 6
- Start Page
- 466
- End Page
- 471
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/27363
- DOI
- 10.5483/BMBRep.2008.41.6.466
- ISSN
- 1976-6696
- Abstract
- Three isoforms of pig PDE4B were cloned and classified as two forms: PDE4B1 and PDE4B3, which contain UCR1 and UCR2; and PDE4B2, which contains only UCR2. The amino acid sequences of each isoform showed good conservation in human and rat PDE4B2 is expressed in a wide range of tissues, but PDE4B1 and PDE4B3 are not Using an informative SNP for the Iberian x Landrace intercross detected from intron 12, a linkage map was constructed. The location of PDE4B was estimated at 123.6 cM outside of the QTL-CI (124-128 cM) for IMF. However, the QTL-CI for IMF was reconfirmed with high significance, and its position was narrowed down to an interval of 4 cM (the region defined by markers PDE4B and SW1881). Using radiation hybrid mapping, LEPR, LEPROT, DNAJC6, AK3L1 and AK3L2 were selected as positional and/or functional candidates related to the QTL.
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