Detailed Information
Cited 17 time in 
Cited 17 time in 
Cited 17 time in
Metadata Downloads
Changing expression of the genes related to human hair graying
- Authors
- Choi, Young Jin; Yoon, Tae Jin; Lee, Young Ho
- Issue Date
- Jul-2008
- Publisher
- JOHN LIBBEY EUROTEXT LTD
- Keywords
- genes; hair graying; melanocytes; melanocyte stem cells; microphthalmia transcription factor
- Citation
- EUROPEAN JOURNAL OF DERMATOLOGY, v.18, no.4, pp 397 - 399
- Pages
- 3
- Indexed
- SCIE
SCOPUS
- Journal Title
- EUROPEAN JOURNAL OF DERMATOLOGY
- Volume
- 18
- Number
- 4
- Start Page
- 397
- End Page
- 399
- ISSN
- 1167-1122
1952-4013
- Abstract
- Hair graying is one of the prototypical signs of human aging, but its mechanism is largely unknown. To elucidate the mechanism of hair graying, we investigated gene expression related to melanogenesis in human hair. The key molecules in melanogenesis, microphthalmiaassociated transcription factor-M (MITF-M), Sox10, Pax3, tyrosine rel- ated protein-1 (TRP-1), and tyrosmase, were absent or greatly reduced in the bulbs of white hair compared to black hair. Melanocyte stem cells (MSCs) or melanocytes express markers for neural crest cells, Sox,10, Pax3, and MITF-M. Taken together, our data suggest that hair graying is caused by defective migration of MSCs into the bulb area of hair.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.