Antibacterial effects of Mume Fructus Water Extract against Salmonella typhimurium in Murine Salmonellosis

Abstract

The present study was undertaken to estimate the antibacterial effect of Mume Fructus water extract (MFWE) against murine salmonellosis. At MFWE concentrations ranging from 25 to 100 ㎍/㎖, the antibacterial effect was not showed on Salmonella typhimurium (S. typhimurium). On the other hand, bacteria without MFWE had a tendency to proliferate up to 8 h after incubation. Oral administration of MFWE at the dose of 40 ㎎/㎖ showed a therapeutic effect for S. typhimurium infected BALB/c mice. The mortality of MFWE-treated mice was 80% at 12 days, while that of MFWE-untreated mice was 100% at 9 days after a lethal dose of S. typhimurium infection. The results of our study strongly indicate that MFWE has potential as an effective of salmonellosis.