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Development of Multilayered Droplet Splitting Microfluidic System for Preparation of Microdroplet

Authors
Kim, C.M.Kim, G.M.
Issue Date
2022
Publisher
Korean Society for Precision Engineeing
Keywords
Droplet splitting; Mass production; Microdroplet; Microfluidic system; Multilayered system
Citation
Journal of the Korean Society for Precision Engineering, v.39, no.6, pp.425 - 431
Indexed
SCOPUS
KCI
Journal Title
Journal of the Korean Society for Precision Engineering
Volume
39
Number
6
Start Page
425
End Page
431
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/2640
DOI
10.7736/JKSPE.022.015
ISSN
1225-9071
Abstract
In this study, we present the multilayered symmetrical droplet splitting microfluidic system for preparation of microspheres. The microfluidic device was fabricated by conventional photolithography and PDMS casting. Multiple layers of microfluidic channels for symmetrical droplet splitting were stacked and integrated into a device. Each layer was designed to obtain 16 microdroplets from one droplet by droplet splitting. The droplet size was controlled with flow rate of dispersed phase (DI-water) and continuous phase (Mineral Oil with 3 wt.% SPAN80) by using a syringe pump. The droplet splitting behavior and production rate were analyzed by high-speed camera and inverted microscope in one layer of the microfluidic device. Additionally, the droplet size and size distribution were observed in each layer of the microfluidic device. The droplet size could be controlled by flow control of two phase flows with high uniformity of droplet size less than 5% coefficient of variation. ? 2022 Korean Society for Precision Engineeing. All rights reserved.
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Kim, Chul Min
IT공과대학 (메카트로닉스공학부)
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