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Anti-Invasive Activity of Anthocyanins Isolated from Vitis coignetiae in Human Hepatocarcinoma Cells
- Authors
- Shin, Dong Yeok; Lee, Won Sup; Kim, Seok Hyun; Kim, Min Jeong; Yun, Jeong Won; Lu, Jing Nan; Lee, Sung Joong; Tsoy, Irina; Kim, Hye Jung; Ryu, Chung Ho; Kim, Gi Young; Kang, Ho Sung; Shin, Sung Chul; Choi, Yung Hyun
- Issue Date
- Oct-2009
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- anthocyanins; Hep3B cell; invasion; matrix metalloproteinase-2; matrix metalloproteinase-9; meoru; nuclear factor kappa B
- Citation
- JOURNAL OF MEDICINAL FOOD, v.12, no.5, pp.967 - 972
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 12
- Number
- 5
- Start Page
- 967
- End Page
- 972
- ISSN
- 1096-620X
- Abstract
- We investigated anti-invasive effects of the anthocyanins from fruits of Vitis coignetiae Pulliat (known as meoru in Korea) on human hepatoma Hep3B cells. The anthocyanins inhibited cell invasion in a dose-dependent manner as measured by Matrigel(TM) (BD Biosciences, San Jose, CA, USA) invasion assays. They also inhibited expression of matrix metalloproteinase (MMP)-2 and MMP-9 and activation of nuclear factor kappa B (NF-kappa B) stimulated by tumor necrosis factor alpha. Taken together, the results of this study indicate that the anthocyanins isolated from fruits of V. coignetiae Pulliat have anti-invasive effects on human hepatoma Hep3B cells and inhibit MMP-2 and MMP-9 gene expression at least in part through the inhibition of NF-kB activation.
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