Persistent Exposure to 2,3 ',4,4 ',5-Pentachlorobiphenyl (PCB118) Induces Hyperalphacholesterolemia in Ratsopen access
- Authors
- Han, Dae-Yong; Park, Hyeon-Soo; Park, Kwang-Il; Kang, Sang-Rim; Cho, Jae-Hyeon; Lee, Won-Sup; Kim, Eun-Ju; Kim, Eun-Hee; Kim, Gon-Sup
- Issue Date
- Dec-2009
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Keywords
- 2,3 ' ,4,4 ' ,5-pentachlorobiphenyl; hyperalphacholesterolemia; apolipoprotein A-I
- Citation
- JOURNAL OF HEALTH SCIENCE, v.55, no.6, pp.901 - 909
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF HEALTH SCIENCE
- Volume
- 55
- Number
- 6
- Start Page
- 901
- End Page
- 909
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/26082
- DOI
- 10.1248/jhs.55.901
- ISSN
- 1344-9702
- Abstract
- Polychlorinated biphenyls (PCBs) are synthetic organic compounds with two phenyl groups well known environmental pollutants. This study examined the effect of persistent exposure to 2,3',4,4',5-pentachlorobiphenyl (PCB118) on serum cholesterol levels in male rats. Male Sprague Dawley rats were administered weekly intraperitoneal injections of either PCB118 (20 mg/kg) dissolved in corn oil or corn oil alone. One week after 2 and 5 administrations, the rats were sacrificed by a pentobarbital injection, and the effect of PCB118 on the serum levels of total cholesterol, high density lipoprotein-cholesterol (HDL-cholesterol), and low density lipoprotein-cholesterol (LDL-cholesterol) was investigated. The protein expression level of apolipoprotein A-I (apo A-I) and 3-hydroxy-3-methylgulutaryl coenzyme A (HMG-CoA) reductase was also examined. In this study, the administration of PCB 118 induced hyperalphacholesterolemia in rats. In addition, the protein expression level of HMG-CoA reductase and apo A-I was higher in the PCB118-treated rats than in the control. These results suggest that the hyperalphacholesterolemia induced by PCB118 in male rats may be associated with an increase in HMG-CoA reductase and apo A-I expression.
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