대유행 인플루엔자(H1N1 2009) 감염과 연관된 폐쇄 세기관지 기질화 폐렴 1예

Abstract

Several types of influenza-related pneumonia have been reported. Bronchiolitis obliterans organizing pneumonia (BOOP) is a nonspecific lung injury. A 64-yearold man sought care to an emergency room due to breathing difficulties. He was diagnosed with pandemic influenza (H1N1 2009) by the real-time polymerase chain reaction (PCR) and was suspected of concomitant bacterial pneumonia. Therefore he was treated with oseltamivir and broad spectrum antibiotics. The disease progressed rapidly despite treatment, so a corticosteroid was added. The trans-bronchial lung biopsy was consistent with BOOP. Here,we investigated BOOP associated with the pandemic influenza (H1N1 2009)virus that was successfully treated with a combination of antiviral, antibacterial and corticosteroid drugs. Although BOOP associated with influenza is rare,combined disease should be suspected especially when the pneumonia does not response to antiviral agents and antibiotics.