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Identification and characterization of a truncated isoform of NELL2
- Authors
- Kim, Dong-Gyu; Hwang, Eun Mi; Yoo, Jae Cheal; Kim, Eunju; Park, Nammi; Rhee, Sangmyung; Ha, Chang Man; Hong, Seong-Geun; Park, Jae-Yong
- Issue Date
- 1-Jan-2010
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Keywords
- NELL2; Truncated NELL2; Alternative splicing; Neurite outgrowth; Secretion
- Citation
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.391, no.1, pp 529 - 534
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Volume
- 391
- Number
- 1
- Start Page
- 529
- End Page
- 534
- ISSN
- 0006-291X
1090-2104
- Abstract
- NELL2 is a neuron-specific secreted glycoprotein containing in N-terminal thrombospondin I-like domain (TSP-N) In this study. we describe NELL2-Tsp, a novel alternative splice variant of rat NELL2 NELL2-Tsp uses an alternate stop codon resulting in a C-terminal truncated form of NELL2, containing a signal peptide and a TSP-N domain NELL2-Tsp is a glycosylated protein specifically expressed In brain tissue. NELL2-Tsp and NELL2 are secreted, likely due to the putative signal peptide. However. Clue to the truncation, the secreted portion of NELL2-Tsp is smaller than that of NELL2 Immunoprecipitation analysis confirmed that NELL2-Tsp was able to associate with NELL2 and with itself In addition, expression of NELL2-Tsp notably reduced secretion of NELL2 and inhibited NELL2-mediated neurite Outgrowth These results suggest that NELL2-Tsp may act as a negative regulator of wild-type NELL2 (C) 2009 Elsevier Inc All rights reserved
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