Detailed Information
Cited 30 time in 
Cited 31 time in 
Cited 31 time in
Metadata Downloads
Transmembrane 4 L Six Family Member 5 (TM4SF5) Enhances Migration and Invasion of Hepatocytes for Effective Metastasis
- Authors
- Lee, Sin-Ae; Kim, Tae You; Kwak, Tae Kyoung; Kim, Hyeonjung; Kim, Semi; Lee, Hyo Jeong; Kim, Sung-Hoon; Park, Ki Hun; Kim, Hyun Jeong; Cho, Moonjae; Lee, Jung Weon
- Issue Date
- 1-Sep-2010
- Publisher
- WILEY
- Keywords
- INVADOPODIA; MIGRATION; INVASION; Tm4SF5; MMP; METASTASIS
- Citation
- JOURNAL OF CELLULAR BIOCHEMISTRY, v.111, no.1, pp 59 - 66
- Pages
- 8
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- JOURNAL OF CELLULAR BIOCHEMISTRY
- Volume
- 111
- Number
- 1
- Start Page
- 59
- End Page
- 66
- ISSN
- 0730-2312
1097-4644
- Abstract
- Overexpression of transmembrane 4 L SIX family member 5 (TM4SF5), a four-transmembrane L6 family member, causes aberrant cell proliferation and angiogenesis, but the roles of TM4SF5 in migration, invasion. and tumor metastasis remain unknown Using in vitro hepatocarcinoma cells that ectopically or endogenously express TM4SF5 and in vivo mouse systems, roles of TM4SF5 in metastatic potentials were examined We found that TM4SF5 expression facilitated migration, invadopodia formation. MMP activation, invasion, and eventually lung metastasis in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects Altogether, TM4SF5-mediated migration and invasion suggest that TM4SF5 may be therapeutically targeted to deal with TM4SF5-mediated hepatocellular cancers J. Cell. Biochem. 111: 59-66, 2010 (C) 2010 Wiley-Liss. Inc
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - ETC > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.