Detailed Information
Cited 15 time in 
Cited 14 time in 
Cited 14 time in
Metadata Downloads
Sequence discrimination of the Z alpha domain of human ADAR1 during B-Z transition of DNA duplexesopen access
- Authors
- Seo, Yeo-Jin; Ahn, Hee-Chul; Lee, Eun-Hae; Bang, Jongchul; Kang, Young-Min; Kim, Hee-Eun; Lee, Yeon-Mi; Kim, Kyungmin; Choi, Byong-Seok; Lee, Joon-Hwa
- Issue Date
- 22-Oct-2010
- Publisher
- WILEY
- Keywords
- NMR; Z-DNA; Hydrogen exchange; Z-DNA binding protein; B-Z transition; Non-CG repeat DNA
- Citation
- FEBS LETTERS, v.584, no.20, pp 4344 - 4350
- Pages
- 7
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- FEBS LETTERS
- Volume
- 584
- Number
- 20
- Start Page
- 4344
- End Page
- 4350
- ISSN
- 0014-5793
1873-3468
- Abstract
- The Z alpha domain of human ADAR1 (Z alpha(ADAR1)) preferentially binds Z-DNA rather than B-DNA with high binding affinity. Z alpha(ADAR1) binds to the Z-conformation of both non-CG-repeat DNA duplexes and a d(CGCGCG)(2) duplex similarly. We performed NMR experiments on complexes between the Z alpha(ADAR1) and non-CG-repeat DNA duplexes, d(CACGTG)(2) or d(CGTACG)(2), with a variety of protein-DNA molar ratios. Comparison of these results with those from the analysis of d(CGCGCG)(2) in the previous study suggests that Za(ADAR1) exhibits the sequence preference of d(CGCGCG)(2) >> d(CACGTG)(2) > d(CGTACG)(2) through multiple sequence discrimination steps during the B-Z transition. (C)2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 자연과학대학 > 화학과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.