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A bisdesmosidic cholestane glycoside from the rhizomes of Polygonatum sibiricum
- Issue Date
- 2011
- Keywords
- Cholestane glycoside; Cytotoxic activity; Polygonatum sibiricum; Spectroscopic methods
- Citation
- Natural Product Sciences, v.17, no.3, pp 183 - 188
- Pages
- 6
- Indexed
- SCOPUS
KCI
- Journal Title
- Natural Product Sciences
- Volume
- 17
- Number
- 3
- Start Page
- 183
- End Page
- 188
- ISSN
- 1226-3907
- Abstract
- A bisdesmosidic cholestane glycoside was isolated from the rhizomes of Polygonatum sibiricum and the structure was elucidated by spectroscopic methods and acid hydrolysis as (22S)-cholest-5-ene-1β,3β,16β,22- tetrol 1-O-α-L-rhamnopyranosyl 16-O-β-D-glucopyranoside. This compound exhibited weak cytotoxic activity with the IC 50 value, 63.6 μM in human MCF-7 breast cancer line, whereas it failed to show agonistic activity at 100 μM in TGR5 assay with Chinese hamster ovary (CHO) cells. This is the first report of a bisdesmosidic cholestane glycoside from Polygonatum species and the full assignments of 1H, 13C NMR by HMBC, TOCSY and NOESY experiments were provided.
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