Identification of Acvr2a as a Th17 Cell-Specific Gene Induced during Th17 Differentiation
- Authors
- Ihn, Hyun-ju; Kim, Dong Hyeok; Oh, Sang-Seok; Moon, Chaerin; Chung, Jin Woong; Song, Hyunkeun; Kim, Kwang Dong
- Issue Date
- Nov-2011
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- helper type 17 T cell (Th17); Acvr2a; TGF-beta; IL-6; all trans retinoic acid (ATRA)
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.75, no.11, pp.2138 - 2141
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 75
- Number
- 11
- Start Page
- 2138
- End Page
- 2141
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/23500
- DOI
- 10.1271/bbb.110436
- ISSN
- 0916-8451
- Abstract
- IL-17-producing T lymphocytes have been found to comprise a distinct lineage of T helper cells (Th17 cells) that are major causes of autoimmune diseases such as EAE, RA, and IBD. In this study, we found that activin receptor type-2A (Acvr2a) is a gene induced during the differentiation of this effector cell lineage as compared with naive T cells. The transcript of Acvr2a was not induced in Th1 and Th2 cells, and both TGF-beta and IL-6 were required for the induction of Acvr2a. When the differentiation of Th17 cells was inhibited by all tarans retinoic acid (ATRA) which induces regulatory T cell (Treg) differentiation under Th17 differentiation conditions, expression of Acvr2a was also inhibited. Hence we propose that Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1, Th2, and Treg.
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