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Isolation and identification of compound from dropwort (Oenanthe javanica) with protective potential against oxidative stress in HepG2 cells
- Authors
- Choi, Heejung; You, Yanghee; Hwang, Kwontack; Lee, Jeongmin; Chun, Jiyeon; Chung, Jin Woong; Shim, Sangin; Park, Chang-Soo; Jun, Woojin
- Issue Date
- Dec-2011
- Publisher
- SPRINGER
- Keywords
- dropwort (Oenanthe javanica); HepG2 cell; caffeic acid; oxidative stress
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.20, no.6, pp 1743 - 1746
- Pages
- 4
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 20
- Number
- 6
- Start Page
- 1743
- End Page
- 1746
- ISSN
- 1226-7708
2092-6456
- Abstract
- The protective effect of dropwort (Oenanthe javanica) was investigated in HepG2 cells under oxidative stress, and its active compound was identified. Compared to H(2)O(2)-alone treated cells, a drastic increase (35%) in protective activity was observed in the cells pretreated with 80% ethanol extract (OJE) of dropwort, suggesting that OJE possessed a potent hepatoprotectant. After a sequential procedure consisting of solvent-partitioning chromatography, TLC, and HPLC was conducted, the compound with proven hepatoprotective activity from OJE was isolated and identified as caffeic acid. Results indicated that caffeic acid in dropwort contributed to this herb's protective profile against oxidative stress-induced liver damage.
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