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Controlled drug delivery from mesoporous silica using a pH-response release system
- Issue Date
- 2012
- Publisher
- ROYAL SOC CHEMISTRY
- Citation
- NEW JOURNAL OF CHEMISTRY, v.36, no.8, pp 1616 - 1620
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- NEW JOURNAL OF CHEMISTRY
- Volume
- 36
- Number
- 8
- Start Page
- 1616
- End Page
- 1620
- ISSN
- 1144-0546
1369-9261
- Abstract
- Mesoporous hollow silica nanoparticles were functionalized with phenanthroline (P-MHS) to prepare a carrier for a host-guest complex. Curcumin was selected as a model drug molecule. The phenanthroline attached to the P-MHS was complexed with Cu2+ through a coordination bond. When the Cu2+-P-MHS was exposed to similar to pH 5, the curcumin was efficiently released into the aqueous phase within 120 min. This work describes a method for functionalizing the surface of the porous silica nanoparticles in a well-defined manner. The P-MHS carrier exhibited controlled release of a model drug under acidic pH conditions.
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