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A new pancreatic lipase inhibitor from Broussonetia kanzinoki
- Authors
- Ahn, Jong Hoon; Liu, Qing; Lee, Chul; Ahn, Mi-Jeong; Yoo, Hwan-Soo; Hwang, Bang Yeon; Lee, Mi Kyeong
- Issue Date
- 15-Apr-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Broussonetia kanzinoki; Moraceae; Pancreatic lipase; Broussonone Lambda; Adipocyte differentiation
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.8, pp 2760 - 2763
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 8
- Start Page
- 2760
- End Page
- 2763
- ISSN
- 0960-894X
1464-3405
- Abstract
- A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4 '-dihydroxyflavan (4), 3 ',7-dihydroxy-4 '-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4 '-methoxyflavone (6), 3,7,3 '-trihydroxy-4 '-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC50 of 28.4 mu M. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay. (C) 2012 Elsevier Ltd. All rights reserved.
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