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A new pancreatic lipase inhibitor from Broussonetia kanzinoki
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ahn, Jong Hoon | - |
| dc.contributor.author | Liu, Qing | - |
| dc.contributor.author | Lee, Chul | - |
| dc.contributor.author | Ahn, Mi-Jeong | - |
| dc.contributor.author | Yoo, Hwan-Soo | - |
| dc.contributor.author | Hwang, Bang Yeon | - |
| dc.contributor.author | Lee, Mi Kyeong | - |
| dc.date.accessioned | 2022-12-27T01:48:40Z | - |
| dc.date.available | 2022-12-27T01:48:40Z | - |
| dc.date.issued | 2012-04-15 | - |
| dc.identifier.issn | 0960-894X | - |
| dc.identifier.issn | 1464-3405 | - |
| dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/22228 | - |
| dc.description.abstract | A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4 '-dihydroxyflavan (4), 3 ',7-dihydroxy-4 '-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4 '-methoxyflavone (6), 3,7,3 '-trihydroxy-4 '-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC50 of 28.4 mu M. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay. (C) 2012 Elsevier Ltd. All rights reserved. | - |
| dc.format.extent | 4 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
| dc.title | A new pancreatic lipase inhibitor from Broussonetia kanzinoki | - |
| dc.type | Article | - |
| dc.publisher.location | 영국 | - |
| dc.identifier.doi | 10.1016/j.bmcl.2012.02.088 | - |
| dc.identifier.scopusid | 2-s2.0-84862782786 | - |
| dc.identifier.wosid | 000302768200024 | - |
| dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.8, pp 2760 - 2763 | - |
| dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
| dc.citation.volume | 22 | - |
| dc.citation.number | 8 | - |
| dc.citation.startPage | 2760 | - |
| dc.citation.endPage | 2763 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | sci | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
| dc.subject.keywordPlus | ORLISTAT | - |
| dc.subject.keywordPlus | OBESITY | - |
| dc.subject.keywordAuthor | Broussonetia kanzinoki | - |
| dc.subject.keywordAuthor | Moraceae | - |
| dc.subject.keywordAuthor | Pancreatic lipase | - |
| dc.subject.keywordAuthor | Broussonone Lambda | - |
| dc.subject.keywordAuthor | Adipocyte differentiation | - |
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