Detailed Information
Cited 37 time in 
Cited 38 time in 
Cited 38 time in
Metadata Downloads
Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors
- Authors
- Han, Sun-Young; Choi, Jie Won; Yang, Jeon; Chae, Chong Hack; Lee, Jongkook; Jung, Heejung; Lee, Kwangho; Ha, Jae Du; Kim, Hyoung Rae; Cho, Sung Yun
- Issue Date
- Apr-2012
- Publisher
- Pergamon Press Ltd.
- Keywords
- Cancer; VEGFR-2; KDR kinase; Imidazo[4,5-c]pyridine; Quinolin-2-one
- Citation
- Bioorganic & Medicinal Chemistry Letters, v.22, no.8, pp 2837 - 2842
- Pages
- 6
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Bioorganic & Medicinal Chemistry Letters
- Volume
- 22
- Number
- 8
- Start Page
- 2837
- End Page
- 2842
- ISSN
- 0960-894X
1464-3405
- Abstract
- A series of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones have been identified as a new class of VEGFR-2 kinase inhibitors. A variety of (4,5,6,7-tetrahydro-imidazo[5,4-c]pyridin-2-yl)-acetic acid ethyl esters were synthesized, and their VEGFR-2 inhibitory activity was evaluated. Described herein are the preparation of the series and the effects of the compounds on VEGFR-2 kinase activity. (C) 2012 Elsevier Ltd. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 약학대학 > 약학과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.