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Cited 37 time in webofscience Cited 38 time in scopus
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Design and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors

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dc.contributor.authorHan, Sun-Young-
dc.contributor.authorChoi, Jie Won-
dc.contributor.authorYang, Jeon-
dc.contributor.authorChae, Chong Hack-
dc.contributor.authorLee, Jongkook-
dc.contributor.authorJung, Heejung-
dc.contributor.authorLee, Kwangho-
dc.contributor.authorHa, Jae Du-
dc.contributor.authorKim, Hyoung Rae-
dc.contributor.authorCho, Sung Yun-
dc.date.accessioned2022-12-27T01:48:32Z-
dc.date.available2022-12-27T01:48:32Z-
dc.date.issued2012-04-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/22223-
dc.description.abstractA series of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones have been identified as a new class of VEGFR-2 kinase inhibitors. A variety of (4,5,6,7-tetrahydro-imidazo[5,4-c]pyridin-2-yl)-acetic acid ethyl esters were synthesized, and their VEGFR-2 inhibitory activity was evaluated. Described herein are the preparation of the series and the effects of the compounds on VEGFR-2 kinase activity. (C) 2012 Elsevier Ltd. All rights reserved.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherPergamon Press Ltd.-
dc.titleDesign and synthesis of 3-(4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridin-2-yl)-1H-quinolin-2-ones as VEGFR-2 kinase inhibitors-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2012.02.073-
dc.identifier.scopusid2-s2.0-84862783839-
dc.identifier.wosid000302768200041-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.22, no.8, pp 2837 - 2842-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume22-
dc.citation.number8-
dc.citation.startPage2837-
dc.citation.endPage2842-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusENDOTHELIAL GROWTH-FACTOR-
dc.subject.keywordPlusORAL MULTIKINASE INHIBITOR-
dc.subject.keywordPlusCANCER-THERAPY-
dc.subject.keywordPlusANGIOGENESIS-
dc.subject.keywordPlusBEVACIZUMAB-
dc.subject.keywordPlusPHARMACOKINETICS-
dc.subject.keywordPlusNAPHTHAMIDES-
dc.subject.keywordPlusRECEPTORS-
dc.subject.keywordPlusSUNITINIB-
dc.subject.keywordPlusANTIBODY-
dc.subject.keywordAuthorCancer-
dc.subject.keywordAuthorVEGFR-2-
dc.subject.keywordAuthorKDR kinase-
dc.subject.keywordAuthorImidazo[4,5-c]pyridine-
dc.subject.keywordAuthorQuinolin-2-one-
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