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Cytotoxic cytochalasins from the endozoic fungus Phoma sp of the giant jellyfish Nemopilema nomurai
- Authors
- La Kim, Eun; Li, Jian Lin; Dang, Hung The; Hong, Jongki; Lee, Chong-Ok; Kim, Dong-Kyoo; Yoon, Won Duk; Kim, Euikyung; Liu, Yonghong; Jung, Jee H.
- Issue Date
- 1-May-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Cytochalasin; Jellyfish-derived fungus; Phoma sp.; Nemopilema nomurai; Cytotoxicity
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.9, pp 3126 - 3129
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 9
- Start Page
- 3126
- End Page
- 3129
- ISSN
- 0960-894X
1464-3405
- Abstract
- Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereo-chemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC50 values in the range of 0.5-30 mu M. The cytochalasin B (5) showed obvious cytotoxicity with IC50 of 7.9 mu M against HeLa human cervical carcinoma cells. (C) 2012 Elsevier Ltd. All rights reserved.
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