Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Aktopen access
- Authors
- Han, Min Ho; Lee, Won Sup; Lu, Jing Nan; Kim, Gonsup; Jung, Jin Myung; Ryu, Chung Ho; Kim, Gi-Young; Hwang, Hye Jin; Kwon, Taeg Kyu; Choi, Yung Hyun
- Issue Date
- Jun-2012
- Publisher
- SPANDIDOS PUBL LTD
- Keywords
- Citrus aurantium L; Akt; apoptosis; leukemia; U937 cells
- Citation
- INTERNATIONAL JOURNAL OF ONCOLOGY, v.40, no.6, pp.2090 - 2096
- Indexed
- SCIE
SCOPUS
- Journal Title
- INTERNATIONAL JOURNAL OF ONCOLOGY
- Volume
- 40
- Number
- 6
- Start Page
- 2090
- End Page
- 2096
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/22144
- DOI
- 10.3892/ijo.2012.1350
- ISSN
- 1019-6439
- Abstract
- Citrus fruits have been used as edible fruits and a traditional medicine since ancient times. In particular, the peels of immature citrus fruits are frequently prescribed in concert with other support herbs for many types of disease including cancer. We investigated the anti-proliferative activity of the peels of Citrus aurantium L. along with their effects on apoptosis. We prepared crude methanol extracts of the peels of Citrus aurantium L. (CMEs) and performed experiments using U937 human leukemia cells. The growth of U937 cells was inhibited by CME treatment in a dose-dependent manner, and CM E induced caspase-dependent apoptosis. CME inhibited the expression of XIAP and Bcl-xL which are anti-apoptotic proteins. CME inhibited Akt activity in a dose-dependent manner. The apoptotic activity of CME was significantly attenuated by Akt augmentation. In conclusion, this study suggested that CME should induce caspase-dependent apoptosis at least in part through Akt inhibition, providing evidence that CMEs have anticancer activity on human leukemia cells.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
- College of Medicine > Department of Medicine > Journal Articles
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