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Synthesis and structure-activity relationship of aminopyridines with substituted benzoxazoles as c-Met kinase inhibitors
- Authors
- Lee, Jongkook; Han, Sun-Young; Jung, Heejung; Yang, Jeon; Choi, Jie-Won; Chae, Chong Hack; Park, Chi Hoon; Choi, Sang Un; Lee, Kwangho; Du Ha, Jae; Lee, Chong Ock; Ryu, Jae Wook; Kim, Hyoung Rae; Koh, Jong Sung; Cho, Sung Yun
- Issue Date
- Jun-2012
- Publisher
- Pergamon Press Ltd.
- Keywords
- Cancer; c-Met kinase; Aminopyridine; Benzoxazole
- Citation
- Bioorganic & Medicinal Chemistry Letters, v.22, no.12, pp 4044 - 4048
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Bioorganic & Medicinal Chemistry Letters
- Volume
- 22
- Number
- 12
- Start Page
- 4044
- End Page
- 4048
- ISSN
- 0960-894X
1464-3405
- Abstract
- A series of hydroxybenzoxazole derivatives was synthesized, and their c-Met kinase inhibitory activity was evaluated. Described herein is a potent c-Met inhibitor by structural modification of the parent benzoxazole scaffold, with particular focus on the hydroxyl substituent of the benzoxazole moiety. (C) 2012 Elsevier Ltd. All rights reserved.
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