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Induction of the cell cycle arrest and apoptosis by flavonoids isolated from Korean Citrus aurantium L. in non-small-cell lung cancer cells
- Authors
- Park, Kwang Il; Park, Hyeon Soo; Nagappan, Arulkumar; Hong, Gyeong Eun; Lee, Do Hoon; Kang, Sang Rim; Kim, Jin A.; Zhang, Jue; Kim, Eun Hee; Lee, Won Sup; Shin, Sung Chul; Hah, Young Sool; Kim, Gon Sup
- Issue Date
- 15-Dec-2012
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Korean Citrus aurantium L.; Flavonoid; Human lung cancer cells; Cell cycle arrest; Apoptosis
- Citation
- FOOD CHEMISTRY, v.135, no.4, pp.2728 - 2735
- Indexed
- SCIE
SCOPUS
- Journal Title
- FOOD CHEMISTRY
- Volume
- 135
- Number
- 4
- Start Page
- 2728
- End Page
- 2735
- ISSN
- 0308-8146
- Abstract
- This study investigated the anti-proliferative and apoptotic effect of flavonoids isolated from Korean Citrus aurantium L using A549 lung cancer cells. Flavonoids potently inhibited of A549 cells in a dose-dependent manner, whereas flavonoids had a weak inhibitory effect on proliferation of WI-38 cells. Flow cytometry and Western blot analysis showed that flavonoids induced cell cycle arrest at the G2/M check-point by controlling the proteins expression level of cyclin B1, cdc2, cdc25c and p21(WAF1/CIP1). Also, flavonoids induced apoptosis through the regulation of the expression of caspases, cleaved PARP and Bax/Bcl-xL ratio. The activity of caspase-3 on A549 cells increased in a dose-dependent manner. These results clearly indicated that the anti-cancer effect of flavonoids on A549 cells follows multiple cellular pathways through G2/M arrest and the induction of apoptosis. (C) 2012 Elsevier Ltd. All rights reserved.
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